Extracellular matrix turnover and outflow resistance

Extracellular Matrix Turnover: a Balance between MMPs and their Inhibitors

3. Avădanei R, Căruntu ID, Amălinei C, Lozneanu L, Balan R, Grigoraş A, et al. High variability in MMP2/TIMP2 and MMP9/TIMP1 expression in secondary liver tumors. Rom J Morphol Embryol. 2013;54(3):479-85. 4. Cogni AL, Farah E, Minicucci MF, Azevedo PS, Okoshi K, Matsubara BB, et al. Metalloproteinases-2 and -9 predict left ventricular remodeling after myocardial infarction. Arq Bras Cardiol. 20...

Accelerated extracellular matrix turnover during exacerbations of COPD

BACKGROUND Exacerbations of chronic obstructive pulmonary disease (COPD) contribute significantly to disease progression. However, the effect on tissue structure and turnover is not well described. There is an urgent clinical need for biomarkers of disease activity associated with disease progression. Extracellular matrix (ECM) turnover reflects activity in tissues and consequently assessment o...

Factors involved in extracellular matrix turnover in human derived cardiomyocytes.

BACKGROUND The molecular mechanisms by which myocardial ischemia translates into ventricular remodeling remain unclear. METHODS We investigated whether hypoxia and proinflammatory cytokines are specific inducers of remodeling signals in an in vitro model of cultured adult human ventricular myocytes (AC16 cells). RESULTS Hypoxia modified the ratio of matrix remodeling factors by increasing t...

Pivotal Role of Matrix Metalloproteinase 13 in Extracellular Matrix Turnover in Idiopathic Pulmonary Fibrosis

RATIONALE Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by excessive deposition of extracellular matrix (ECM). OBJECTIVES We investigated the regulation of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lung fibrosis. METHODS MMP and TIMP expression, collagenolytic activity and collagen content was assessed in IPF (n=16) versus donor (n=6) lung homog...

Editorial: Brain Extracellular Space: Geometry, Matrix and Physiological Importance